| Scramble (Stern) | |
| Scrambled Egg | |
| SD Fighters (Korea) | |
| SD Gundam Neo Battling (Japan) | |
| SD Gundam Psycho Salamander no Kyoui | |
| SDI - Strategic Defense Initiative (bootleg, set 1) | |
| SDI - Strategic Defense Initiative (bootleg, set 2) | |
| SDI - Strategic Defense Initiative (bootleg, set 3) | |
| SDI - Strategic Defense Initiative (bootleg, set 4) | |
| SDI - Strategic Defense Initiative (bootleg, set 5) | |
| SDI - Strategic Defense Initiative (bootleg) | |
| SDI - Strategic Defense Initiative (Japan, newer, System 16A, FD1089B 317-0027) | |
| SDI - Strategic Defense Initiative (Japan, old, System 16A, FD1089B 317-0027) | |
| SDI - Strategic Defense Initiative (System 16B, FD1089A 317-0028) | |
| Search Eye | |
| Search Eye (English / Korean) | |
| Search Eye Plus V2.0 | |
| Secret Agent (Japan revision 2) | |
| Secret Agent (World) | |
| Section Z (set 1) | |
| Section Z (set 2) | |
| Sector Zone | |
| Sega Ninja (315-5102) | |
| Sega Ninja (not encrypted) | |
| Sega Rally Championship - Twin/DX (Revision C) | |
| SegaSonic Bros. (prototype, hack) | |
| SegaSonic Cosmo Fighter (World) | |
| SegaSonic Popcorn Shop (Rev B) | |
| SegaSonic The Hedgehog (Japan, prototype) | |
| SegaSonic The Hedgehog (Japan, rev. C) | |
| Sei Senshi Amatelass | |
| Seicross | |
| Seishun Scandal (315-5132, Japan) | |
| Sel Feena | |
| Sen Jing - Guardian Storm (Japan) | |
| Sen-Know (Japan) | |
| Sengeki Striker (Asia) | |
| Sengeki Striker (Japan) | |
| Sengoku / Sengoku Denshou (NGH-017)(US) | |
| Sengoku / Sengoku Denshou (NGM-017)(NGH-017) | |
| Sengoku 2 / Sengoku Denshou 2 | |
| Sengoku 3 / Sengoku Densho 2001 | |
| Sengoku 3 / Sengoku Densho 2001 (Evolution 1.0, FCHT hack) [Hack] | |
| Sengoku Ace (Japan, set 2) | |
| Sengoku Ace (Japan) | |
| Senjo no Ookami II (Ookami 2 900302 Japan) | |
| Senjou no Ookami | |
| Sexy Parodius (ver JAA) | |
| SF-X [Incomplete Sound] | |
| Shackled (US) | |