| Shining Soul (E)(Patience) | |
| Shining Soul (J)(Eurasia) | |
| Shining Soul (U)(Independent) | |
| Shining Soul II (E)(Menace) | |
| Shining Soul II (J)(Eurasia) | |
| Shining Soul II (U)(Independent) | |
| Shinyaku Seiken Densetsu (J)(Independent) | |
| Shiren Monsters Netsal (J)(Rising Sun) | |
| Shonen Jump's - One Piece (U)(Trashman) | |
| Shonen Jump's Shaman King - Master of Spirits 2 (U)(Trashman) | |
| Shrek - Reekin' Havoc (E)(Independent) | |
| Shrek - Smash n' Crash Racing (U)(Rising Sun) | |
| Shrek - Swamp Kart Speedway (U)(Venom) | |
| Shrek 2 - Beg for Mercy (E)(Rising Sun) | |
| Shrek 2 - Beg for Mercy (U)(Rising Sun) | |
| Shrek 2 (E)(Rising Sun) | |
| Shrek 2 (U)(Independent) | |
| Shrek Hassle at the Castle (E)(Independent) | |
| Shrek Hassle at the Castle (U)(Venom) | |
| Shrek Reekin' Havoc (U)(Mode7) | |
| Shrek Smash n' Crash Racing (E)(sUppLeX) | |
| Shrek SuperSlam (E)(Rising Sun) | |
| Shrek SuperSlam (U)(Trashman) | |
| Shrek The Third (E)(sUppLeX) | |
| Shrek the Third (U)(Sir VG) | |
| Sigma Star Saga (U)(Trashman) | |
| Silent Scope (E)(Independent) | |
| Silent Scope (J)(Evasion) | |
| Silent Scope (U)(Eurasia) | |
| Silk to Cotton (J)(Cezar) | |
| Silvanian Family Yousei no Stick to Fushigi no Marroine no Onnanoko (J)(Rising Sun) | |
| Silver the Hedgehog over Emerl | |
| Sim City 2000 (E)(TrashMan) | |
| Sim City 2000 (U)(GBANow) | |
| Simple 2960 Vol. 1 - The Table Game Collection (J)(Mugs) | |
| Simple 2960 Vol. 2 - The Block Kuzushi (J)(Mugs) | |
| Simple 2960 Vol. 3 - The Itsudemo Puzzle (J)(Rising Sun) | |
| Simple 2960 Vol. 4 - The Trump (J)(Rising Sun) | |
| Sister Princess Re Pure (J)(Polla) | |
| Sitting Ducks (E)(Rising Sun) | |
| Sitting Ducks (U)(Chameleon) | |
| SK8 - Tony Hawk's Pro Skater 2 (J)(Independent) | |
| Sky Dancers - They Magically Fly! (E)(Sir VG) | |
| Sky Dancers (U)(Trashman) | |
| Slime Morimori Dragon Quest - Shougeki no Shippo Dan (J)(Independent) | |
| Slot-Pro Advance - Takarafune & Oedoshima Fubuki 2 (J)(Independent) | |
| SLOT!PRO 2 Advance GoGo Juggler (J)(Mugs) | |
| Smashing Drive (E)(Independent) | |
| Smashing Drive (U)(Venom) | |
| Smuggler's Run (E)(Squirrels) | |