| Car Licence (Japan) | |
| Casino Funpak (USA) | |
| Castle of Illusion Starring Mickey Mouse (USA, Europe) | |
| Chakan (USA, Europe) | |
| Chessmaster, The (USA, Europe) | |
| Chicago Syndicate (USA, Europe) | |
| Choplifter III (USA, Europe) | |
| Chuck Rock (World) | |
| Chuck Rock II - Son of Chuck (Europe) | |
| Chuck Rock II - Son of Chuck (USA) | |
| Cliffhanger (USA, Europe) | |
| Clutch Hitter (USA, Europe) | |
| Coca Cola Kid (Japan) | |
| Coca Cola Kid (Japan) [En by Filler v1.0] | |
| Columns (Japan) | |
| Columns (USA, Europe) | |
| Cool Spot (USA, Europe) | |
| Cosmic Spacehead (Europe) | |
| Crayon Shin-chan - Taiketsu! Kantam Panic!! (Japan) | |
| Crazy Faces (Prototype) | |
| Crystal Warriors (USA, Europe) | |
| Cutthroat Island (USA, Europe) | |
| Daffy Duck in Hollywood (Europe) (En,Fr,De,Es,It) | |
| Deep Duck Trouble Starring Donald Duck (USA, Europe) | |
| Defenders of Oasis (USA, Europe) | |
| Desert Speedtrap (Europe) (En,Fr,De,Es,It) | |
| Desert Speedtrap (USA) | |
| Desert Strike - Return to the Gulf (USA, Europe) | |
| Devilish (Europe) | |
| Devilish (Japan) | |
| Devilish (USA) | |
| Donald Duck no 4-Tsu no Hihou (Japan) | |
| Donald Duck no Lucky Dime (Japan) | |
| Donald no Magical World (Japan) (En,Ja) | |
| Doraemon - Waku Waku Pocket Paradise (Japan) | |
| Double Dragon (USA, Europe) | |
| Double Dragon (USA, Europe) (Beta) | |
| Dr. Robotnik's Mean Bean Machine (USA, Europe) | |
| Dragon - The Bruce Lee Story (Europe) | |
| Dragon - The Bruce Lee Story (USA) | |
| Dragon Crystal - Tsurani no Meikyuu (Japan) | |
| Dragon Crystal (USA, Europe) | |
| Dropzone (USA) | |
| Dunk Kids (Japan) | |
| Dynamite Headdy (Earlier Game Gear Prototype) | |
| Dynamite Headdy (Japan) | |
| Dynamite Headdy (USA, Europe) | |
| Earthworm Jim (USA, Europe) | |
| Ecco II - The Tides of Time (USA, Europe) | |
| Ecco the Dolphin (Japan) | |