| S.S. Lucifer - Man Overboard! (Europe) | |
| Samurai Shodown (USA, Europe) | |
| Samurai Spirits (Japan) | |
| Scratch Golf (Japan) | |
| SD Gundam - Winner's History (Japan) | |
| SD Gundam - Winner's History (Japan) [En by Gaijin v0.99] | |
| Sega Game Pack 4 in 1 (Europe) | |
| Sensible Soccer (Europe) | |
| Shadam Crusader - Harukanaru Oukoku (Japan) | |
| Shanghai II (Japan) | |
| Shaq Fu (USA, Europe) | |
| Shikinjou (Japan) | |
| Shining Force Gaiden - Ensei, Jashin no Kuni e (Japan) | |
| Shining Force Gaiden - Final Conflict (Japan) | |
| Shining Force Gaiden - Final Conflict (Japan) [En by SFCentral v20060707] | |
| Shining Force Gaiden II - Jashin no Kakusei (Japan) | |
| Shining Force II - The Sword of Hajya (USA, Europe) | |
| Side Pocket (USA) | |
| Simpsons, The - Bart vs. The Space Mutants (USA, Europe) | |
| Simpsons, The - Bart vs. The World (USA, Europe) | |
| Skweek (Japan) | |
| Slider (USA, Europe) | |
| Smurfs, The (Europe) (En,Fr,De,Es) | |
| Solitaire Funpak (USA, Europe) | |
| Solitaire Poker (USA, Europe) | |
| Sonic & Tails (Japan) | |
| Sonic & Tails 2 (Japan) | |
| Sonic Blast (World) | |
| Sonic Chaos (USA, Europe) | |
| Sonic Drift (Japan) | |
| Sonic Drift (Japan) (Sample) | |
| Sonic Drift 2 (Japan) | |
| Sonic Labyrinth (USA, Europe) | |
| Sonic Spinball (USA, Europe) | |
| Sonic The Hedgehog - Triple Trouble (USA, Europe) | |
| Sonic The Hedgehog (Japan) | |
| Sonic The Hedgehog (World) (Proto) | |
| Sonic The Hedgehog (World) (v1.1) | |
| Sonic The Hedgehog 2 (World) | |
| Soukoban (Japan) | |
| Space Harrier (USA, Europe) | |
| Spider-Man - Return of the Sinister Six (USA, Europe) | |
| Spider-Man and the X-Men in Arcade's Revenge (USA, Europe) | |
| Spider-Man vs. The Kingpin (USA, Europe) | |
| Spirou (Europe) (Proto) | |
| Sports Illustrated Championship Football & Baseball (USA, Europe) | |
| Sports Trivia - Championship Edition (USA, Europe) | |
| Sports Trivia (USA, Europe) | |
| Star Trek - The Next Generation (USA, Europe) | |
| Star Trek Generations - Beyond the Nexus (USA, Europe) | |