| Sonic Rush Adventure (Korea) | |
| Sonic Rush Adventure (USA) (En,Ja,Fr,De,Es,It) | |
| Sonic Rush Generations | |
| SonicDS | |
| Sonny with a Chance (Europe) (En,Fr,De,Es,It) (NDSi Enhanced) | |
| Sonny with a Chance (USA) (En,Fr,Es) (NDSi Enhanced) | |
| Sonshi no Heihou DS (Japan) | |
| Sonyeojeok Yeonae Hyeongmyeong - Love Revo!! DS (Korea) | |
| Sora no Otoshimono Forte - Dreamy Season (Japan) | |
| Sorcerer's Apprentice, The (Europe) (En,De,Es,It) | |
| Sorcerer's Apprentice, The (USA) (En,Es) | |
| Soreike! Anpanman - Baikinman no Daisakusen (Japan) | |
| Soroban DS (Japan) | |
| Soroeru Puzzle Douwa Oukoku (Japan) | |
| Soul Bubbles (Europe) (En,Fr,De,Es,It) | |
| Soul Bubbles (USA) (En,Fr,De,Es,It) | |
| Soul Eater - Medusa no Inbou (Japan) | |
| Souseiki Gadget Robo (Japan) | |
| Space Bust-A-Move (USA) (En,Fr,De,Es,It) | |
| Space Camp (Europe) (En,Fr,De,Es,It) | |
| Space Camp (USA) (En,Fr) | |
| Space Chimps (Europe) (En,Fr,De,Es,It) | |
| Space Chimps (USA) (En,Fr) | |
| Space Invaders DS (Japan) | |
| Space Invaders Extreme (Europe) (En,Ja,Fr,De,Es,It) | |
| Space Invaders Extreme (Japan) | |
| Space Invaders Extreme (USA) (En,Ja,Fr,De,Es,It) | |
| Space Invaders Extreme 2 (Europe) (En,Ja,Fr,De,Es,It) | |
| Space Invaders Extreme 2 (Japan) | |
| Space Invaders Extreme 2 (USA) (En,Ja,Fr,De,Es,It) | |
| Space Invaders Revolution (Europe) (En,Fr,De,Es,It) | |
| Space Invaders Revolution (USA) (En,Fr,De,Es,It) | |
| Space Puzzle Bobble (Japan) | |
| Spanisch Buddy (Europe) (Fr,De,It) | |
| Spanish for Everyone! (USA) | |
| Spectral Force - Genesis (Europe) | |
| Spectral Force - Genesis (Japan) | |
| Spectral Force - Genesis (Korea) | |
| Spectral Force - Genesis (USA) | |
| Spectrobes - Beyond the Portals (Europe) (En,Fr,De,Es,It,Nl) | |
| Spectrobes - Beyond the Portals (USA) | |
| Spectrobes (Europe) (En,Fr,De,Es,It) | |
| Spectrobes (USA) (En,Fr,De,Es,It) | |
| Speed Racer - The Videogame (Europe) (En,Fr,De,Es,It,Nl) | |
| Speed Racer - The Videogame (USA) (En,Fr,Es,Pt) | |
| Speed Racer (Japan) (En,Ja) | |
| Spellbound (Europe) (En,Fr,De,Es,It) | |
| Spelling Challenges and More! (USA) | |
| Spider-Man - Allie ou Ennemi (France) | |
| Spider-Man - Amici o Nemici (Italy) | |