| Sukashikashipanman DS - 'Shokotan' Koto Nakagawa Shoko Produce (Japan) | |
| Suki Desu Suzuki-kun!! - 4-nin no Suzuki-kun (Japan) | |
| Sumeoinneun Nunui Him - DS Allyeok Training (Korea) | |
| Sumeun Sojireul Kkaeuneun - Geurimgyosil (Korea) (NDSi Enhanced) | |
| Summon Night - Twin Age (USA) | |
| Summon Night (Japan) | |
| Summon Night 2 (Japan) | |
| Summon Night Twin Age - Seirei-tachi no Koe (Japan) | |
| Summon Night X - Tears Crown (Japan) | |
| Sun Crossword Challenge, The (Europe) | |
| Sunday x Magazine - Nettou! Dream Nine (Japan) | |
| Sunrise Anime Zuke - Boku no Joushiki, Kimi no Hijoushiki - Vol. 1 (Japan) | |
| Supa Robo Gakuen (Japan) | |
| Super Auto Salon - Custom Car Contest (Japan) | |
| Super Black Bass - Dynamic Shot (Japan) | |
| Super Black Bass - Kitahankyuu o Tsuru (Japan) | |
| Super Black Bass Fishing (Europe) (En,Fr,De) | |
| Super Black Bass Fishing (USA) | |
| Super Collapse! 3 (USA) | |
| Super Dodgeball Brawlers (USA) | |
| Super Fahrschule (Germany) | |
| Super Fruit Fall (Europe) (En,Fr,De,Es,It) | |
| Super Fruit Fall (USA) | |
| Super Fun Chess (Europe) (En,De,Es,It) | |
| Super Fun Sudoku (Europe) (En,De,Es,It) | |
| Super Kart DS (Formerly MKDS Beta Grand Prix) | |
| Super Kaseki Horider (Japan) (NDSi Enhanced) | |
| Super Mario: Endless Earth | |
| Super Monkey Ball - Touch & Roll (Europe) (En,Fr,De,Es,It) | |
| Super Monkey Ball - Touch & Roll (USA) (En,Fr,De,Es,It) | |
| Super Monkey Ball DS (Japan) | |
| Super Princess Peach (Europe) (En,Fr,De,Es,It) | |
| Super Princess Peach (Japan) | |
| Super Princess Peach (USA) | |
| Super Robot Taisen K (Japan) | |
| Super Robot Taisen L (Japan) | |
| Super Robot Taisen OG Saga - Endless Frontier (USA) | |
| Super Robot Taisen OG Saga - Masou Kishin - The Lord of Elemental (Japan) | |
| Super Robot Taisen W (Japan) | |
| Super Scribblenauts (Europe) (En,Fr,De,Es,It,Nl) | |
| Super Scribblenauts (USA) (En,Fr,Es,Pt) | |
| Super Speed Machines (USA) | |
| Super Star Kartz (USA) (En,Fr) | |
| Superman Returns (Europe) (En,Fr,De,Es,It) | |
| Superman Returns (USA) | |
| Supermodel Makeover by Lauren Luke (Europe) (En,Fr,De,It) | |
| Supervivientes (Spain) | |
| Surf's Up (Europe) (En,Fr,De,Es,It) | |
| Surf's Up (Europe) (En,Fr,Es) | |
| Surf's Up (USA) (En,Fr,Es) | |