| S.C.A.T. - Special Cybernetic Attack Team (USA) | |
| Sack of Flour V1b by CMU NESdev Team | |
| Saint Seiya - Ougon Densetsu (Japan) | |
| Saint Seiya - Ougon Densetsu Kanketsu Hen (Japan) | |
| Saint Seiya - Ougon Densetsu Kanketsu Hen (Japan) (Beta) | |
| Saiyuuki World (Japan) | |
| Saiyuuki World 2 - Tenjoukai no Majin (Japan) | |
| Saiyuuki World 2 - Tenjoukai no Majin (Japan) [En by PentarouZero v1.0] (~Saiyuki World 2 - Evil Spirit of Heaven) | |
| Sakigake!! Otoko Juku - Shippuu Ichi Gou Sei (Japan) | |
| Salad no Kuni no Tomato Hime (Japan) | |
| Salamander (Japan) | |
| Samurai Zombie Nation (USA) | |
| San Guo Zhi - Qun Xiong Zheng Ba (Asia) (Unl) | |
| San Guo Zhong Lie Zhuan (China) (Unl) | |
| Sanada Juu Yuushi (Japan) | |
| Sangokushi - Chuugen no Hasha (Japan) | |
| Sangokushi (Japan) | |
| Sangokushi 2 - Haou no Tairiku (Japan) | |
| Sangokushi 2 (Japan) | |
| Sanma no Mei Tantei (Japan) | |
| Sanrio Carnival (Japan) | |
| Sanrio Carnival 2 (Japan) | |
| Sanrio Carnival 2 (Japan) [En by Suicidal v1.0] | |
| Sanrio Cup - Pon Pon Volley (Japan) | |
| Sanrio Cup - Pon Pon Volley (Japan) [En by Gaijin v1.0] | |
| Sansara Naga (Japan) | |
| Sansuu 1 Nen - Keisan Game (Japan) | |
| Sansuu 2 Nen - Keisan Game (Japan) | |
| Sansuu 3 Nen - Keisan Game (Japan) | |
| Sansuu 4 Nen - Keisan Game (Japan) | |
| Sansuu 4 Nen - Keisan Game (Japan) (Beta) | |
| Sansuu 5 & 6 Nen - Keisan Game (Japan) | |
| Sansuu 5 & 6 Nen - Keisan Game (Japan) (Beta) | |
| Satomi Hakkenden (Japan) | |
| Satory Land | |
| Satsui no Kaisou - Power Soft Satsujin Jiken (Japan) | |
| Satsujin Club (Japan) | |
| Scarabeus (USA) (Sample) | |
| SD Battle Oozumou - Heisei Hero Basho (Japan) | |
| SD Gundam - Gachapon Senshi 2 - Capsule Senki (Japan) | |
| SD Gundam - Gachapon Senshi 3 - Ei | |
| yuu Senki (Japan) | |
| SD Gundam - Gachapon Senshi 4 - NewType Story (Japan) | |
| SD Gundam - Gachapon Senshi 5 - Battle of Universal Century (Japan) | |
| SD Gundam Gaiden - Knight Gundam Monogatari (Japan) | |
| SD Gundam Gaiden - Knight Gundam Monogatari (Japan) (Rev 1) | |
| SD Gundam Gaiden - Knight Gundam Monogatari 2 - Hikari no Kishi (Japan) | |
| SD Gundam Gaiden - Knight Gundam Monogatari 3 - Densetsu no Kishi Dan (Japan) | |
| SD Hero Soukessen - Taose! Aku no Gundan (Japan) | |
| SD Keiji - Blader (Japan) | |
| SD Sengoku Bushou Retsuden (Japan) | |